TABLE 3

Comparison of empirical Bayesian estimates for the final model using total body weight to correct for body size

ParameterMedian (range) for age categorya
>2–6 yrsb>6–12 yrs>12 yrsc
Nonobese (n = 8)Obese (n = 12)Nonobese (n = 15)Obese (n = 20)Nonobese (n = 26)Obese (n = 44)
CL (liters/h)4.17 (0.90–9.10)5.69 (1.84–8.27)12.50 (3.55–34.40)10.70 (4.71–26.70)14.25 (5.56–37.40)19.15 (3.92–33.70)
CL (liters/h/kg)0.23 (0.082–0.78)0.28 (0.11–0.40)0.33 (0.13–0.78)0.22 (0.092–0.64)0.23 (0.064–0.53)0.18 (0.041–0.65)
CL (liters/h/70 kg)10.64 (3.59–35.03)14.83 (5.49–20.32)20.67 (7.08–48.48)14.69 (5.94–39.16)15.82 (4.72–34.68)13.97 (3.12–37.89)
V (liters)15.25 (7.58–19.70)17.60 (8.39–25.20)29.0 (17.50–57.40)46.90 (32.90–85.80)**60.10 (22.50–94.60)85.75 (28.50–160.0)**
V (liters/kg)0.81 (0.69–1.26)0.86 (0.66–1.03)0.90 (0.67–1.06)1.03 (0.66–1.29)0.89 (0.70–1.34)0.89 (0.62–1.58)
Half-life (h)2.41 (1.12–5.85)2.15 (1.53–4.36)2.15 (0.95–5.77)3.03 (1.19–6.26)**2.84 (1.17–7.60)3.55 (0.90–11.30)
  • a Statistically significant differences (**) were observed using a rank sum test.

  • b Three participants with missing height (and BMI) were not included in this parameter summary.

  • c Ten participants (6 nonobese and 4 obese) who were >18 years of age were included in the parameter summary.