Table 2.

Effect of AY on gamma interferon and IL-12 production and cell mortality in PBMCs from patients with AIDSa

Time (days)DonorCytokine production in culture supernatants% Mortality of cultured cells
Gamma interferon (pg/ml)IL-12 (pg/ml)
AY−AY+AY−AY+AY−AY+
10M120200525239
14M115250520288
22M1103007302610
10M210404181810
14M220505205511
22M215707257012
10M3103505301612
14M3103005251312
22M3104005403013
10M4207501050187
14M41560015602510
22M42085020802813
10M520600101002510
14M5155005903211
22M51080051103512
10M61520015150199
14M62025010100298
22M61030051004013
10M710150201002013
14M715180301502712
22M720250251203114
10M81535015902511
14M82040020803514
22M82545025954216
  • a The cells were cultured as described in footnote a of Table 1. The culture supernatants were used to test both gamma interferon and IL-12 levels with an R&D system enzyme-linked immunosorbent assay kit. Mortality was assessed by Trypan blue coloration. Data are expressed as the means for triplicate cultures.