Table 1.

Inhibitory activities of quinolones against type II topoisomerases

QuinoloneActivity (μg/ml) against:
S. aureus MS5935 topoisomerase IVE. coli NIHJ JC-2 DNA gyraseHeLa cell topoisomerase II
IC50MICIC50MICIC50Cytotoxicity
Gatifloxacin13.80.050.1090.0063265122
Clinafloxacin3.230.0250.0450.003229.760.1
Ciprofloxacin11.80.390.0720.003234.4a 105
Sparfloxacin22.30.050.1300.012510272.5
Ofloxacin35.70.390.2110.0125132a 301
TosufloxacinNDb ND0.1650.0125NDND
Levofloxacin19.90.200.1860.0063NDND
Lomefloxacin35.20.390.1710.025238216
Norfloxacin26.00.780.3090.02587.3a 139
Fleroxacin45.70.390.3780.025193a 349
Enoxacin55.40.780.4820.0581.867.9
Pipemidic acid350253.180.78NDND
Nalidixic acid435257.250.78169a 277
  • a Data from previous study (25).

  • b ND, not determined.