Table 3.

Lactacystin inhibits sporozoite infectivity in vivo

No. of sporozoites injectedInhibitoraNo. of mice positive for parasites/no. of mice injectedb on day:
345
100,000None1/1
Lactacystin2/2
10,000None2/2
Lactacystin0/33/3
1,000None3/3
Lactacystin0/33/3
100None0/33/3
Lactacystin0/30/32/3c
  • a Sporozoites were preincubated in medium with 3 μM lactacystin or without lactacystin for 1 h and then injected into mice i.v.

  • b On days 3 to 5 postinjection blood smears were taken from mice and analyzed for the presence of parasites.

  • c The mouse that was negative on day 5 remained negative for the next 7 days.