Table 1.

Lactacystin inhibits development of sporozoites into EEF

ExptInhibitorConcn (μM)No. of EEFa% Inhibition
1b None448 ± 25
Lactacystin1109 ± 1075
35 ± 299
90100
2c None291 ± 5
Lactacystin1156 ± 646
334 ± 588
90100
clasto-Lactacystin  dihydroxy acid9280 ± 326
3d None816 ± 9
Lactacystin1574 ± 1329
3458 ± 1743
9408 ± 350
  • a Number of EEF per 100 high-powered fields.

  • b Inhibitor present for the first 3 h of the experiment.

  • c Parasites were preincubated with inhibitor for 1 h, washed, and then plated on cells.

  • d Inhibitor was added 24 h after parasites were plated on cells. The EEF in the lactacystin-treated wells were smaller than those in the control wells.