Table 4.

Binding of OPC-20011 and reference compounds to PBPs in S. pneumoniae C0096

CompoundIC50 (μg/ml)a
PBP1APBP1BPBP2XPBP2PBP3
OPC-200110.140.081.28>6.4<0.025
ABPC7.160.700.65>6.4<0.025
  • a Binding affinities of test compounds for PBPs are expressed as the concentration (in micrograms per milliliter) required to prevent 50% of the binding of [14C]benzylpenicillin to each PBP.