Table 2.

Antibacterial activities of OPC-20011 and reference compounds against clinical isolates

Organism (no. of strains)CompoundMIC (μg/ml)
RangeMIC50MIC90
MSSA (47)OPC-200110.1–3.130.390.78
CTM0.025–12.50.783.13
FMOX0.39–6.250.781.56
CAZ3.13–5012.525
CPR0.39–251.561.56
IPM0.006–1.560.0060.1
DMPPC1.56–6.253.136.25
VCM0.78–1.560.781.56
MRSA (33)OPC-200110.78–6.256.256.25
CTM100–>100100100
FMOX0.78–10025100
CAZ>100–>100100100
CPR3.13–10050100
IPM0.1–>10050100
DMPPC>100–>100100100
VCM0.78–1.561.561.56
DMPPC-susceptible S. epidermidis(44)OPC-200110.2–1.560.391.56
CTM0.39–3.130.78–3.13
FMOX0.39–12.51.5612.5
CAZ3.13–256.2525
CPR0.39–6.250.783.13
DMPPC1.56–6.253.136.25
VCM0.78–3.131.563.13
DMPPC-resistant S. epidermidis(34)OPC-200110.78–6.251.563.13
CTM1.56–12.53.136.25
FMOX3.13–1002550
CAZ12.5–>10025100
CPR3.13–506.2550
DMPPC12.5–>100100100
VCM1.56–3.131.563.13
E. faecalis (27)OPC-200110.78–6.253.136.25
CTM100–>100100100
FMOX100–>100100100
CAZ–>100100100
CPR12.5–10050100
ABPC1.56–3.131.563.13
ABPC-susceptible S. pneumoniae(27)OPC-20011<0.006–<0.006<0.006
CTM0.025–0.780.20.78
FMOX0.025–0.390.20.39
CAZ0.0125–6.250.20.39
CPR<0.006–0.780.01250.1
ABPC<0.006–0.10.0250.1
VCM0.05–0.20.10.2
Non-ABPC-susceptible S. pneumoniae(18)OPC-20011<0.006–0.050.0250.05
CTM3.13–6.256.256.25
FMOX1.56–6.253.136.25
CAZ1.56–6.253.136.25
CPR0.2–0.780.390.78
ABPC1.56–3.133.133.13
VCM0.05–0.20.10.2
E. coli (54)OPC-200110.39–1.560.781.56
CTM0.1–0.780.20.78
FMOX0.05–0.390.10.2
CAZ0.1–0.780.20.78
CPR0.025–0.20.050.2
K. pneumoniae (26)OPC-200110.1–6.251.563.13
CTM0.1–1.560.20.39
FMOX0.1–0.780.10.1
CAZ0.1–250.20.39
CPR0.05–3.130.10.1
H. influenzae (20)OPC-200110.025–0.20.10.2
CTM0.1–0.780.20.39
FMOX0.78–3.130.781.56
CAZ0.05–0.390.20.2
CPR0.05–0.390.10.2
S. marcescens(27)OPC-200111.56–12.51.566.25
CTM3.13–>10012.5100
FMOX0.78–500.786.25
CAZ0.2–250.390.78
CPR0.05–0.780.10.39
P. mirabilis (41)OPC-200110.05–>1000.391.56
CTM0.2–>1000.78100
FMOX0.2–>1000.39100
CAZ0.05–1000.26.25
CPR<0.006–>1000.11.56
P. rettgeri (40)OPC-200110.39–3.130.781.56
CTM0.05–>1000.39100
FMOX0.05–6.250.13.13
CAZ0.05–6.250.21.56
CPR<0.006–0.390.0250.2
P. aeruginosa (27)OPC-2001112.5–>10025100
CTM–>100100100
FMOX–>100100100
CAZ1.56–503.1350
CPR3.13–10012.550