Table 9.

Binding of OPC-20011 to serum proteins from different animal species

Animal % Binding to serum proteins (± SD)
Mouse29.0 ± 3.0
Rat6.4 ± 2.5
Rabbit<1
Dog5.8 ± 1.5
Monkey1.7 ± 3.1
Human23.2 ± 1.7