Table 3.

Binding of OPC-20011 and reference compounds to PBPs in S. aureus FDA 209-P

CompoundIC50(μg/ml)a
PBP1PBP2PBP3PBP4
OPC-20011NDb 0.0680.0530.065
OPC-20026ND0.3030.5010.199
CTM10.9460.2730.2820.283
CAZND0.360>3.130.327
FMOX32.5450.2120.3701.027
CPRND0.1633.0860.022
  • a Binding affinities of test compounds for PBPs are expressed as the concentration (in micrograms per milliliter) required to prevent 50% of the binding of [14C]benzylpenicillin to each PBP.

  • b ND, not detected.