Table 2.

MICs of different β-lactams for PAe191 and OXA13-1, OXA-19- and OXA-13-producing transformants

Antibiotic + inhibitoraMIC (μg/ml) for the following strains (plasmid/enzyme):
PAe191PAO38 (pAZ310/OXA13-1)PAO38 (pAZ316/OXA-19)PAO38 (pAZ309/OXA-13)bPAO38 (pNJR-32)DH5α (pAZ326/OXA13-1)DH5α (pAZ327/OXA19)DH5α (pK18)
Ampicillin>512>512>512c >5128642
Ticarcillin51264256256168641
 + CLA51264256256168321
Piperacilin1283264322280.5
 + TAZ12816643220.510.5
Cefotaxime12832321616
Ceftazidime512256256228160.12
 + CLA256128128216220.06
 + IMI3216321616
Aztreonam6481682
Cefsulodin646464322
Imipenem11111
Amikacin32168164
Gentamicin2564644
  • a CLA, clavulanic acid (2 μg/ml); TAZ, tazobactam (4 μg/ml); IMI, imipenem (0.25 μg/ml).

  • b Data are from reference20.

  • c —, not determined.