Table 3.

Total kidney burdens of micea

Patient and isolateMedian total kidney burden (105 CFU/mouse) (range) of mice
ControlTreated with FLUb
Patient 7
 412260 (79–800)0.04c (0.01–3.1)
 1907230 (100–730)4.4c (1.1–8)
 23070.005 (<0.001–0.003)0.0003 (<0.001–0.002)
Patient 14
 58024 (7.1–120)0.8c (0.34–4.6)
 6495.5 (0.008–55)2.3c (0.086–7.5)
 24380.15 (0.44–120)0.5 (0.11–4.1)
Patient 43
 16496.6 (2–21)0.03c (0.002–5.4)
 183147 (27–170)11c (1.8–29)
 218357 (10–320)3c (0.92–9.4)
Patient 9
 4374.9 (1.9–7.8)0.03c (0.012–0.34)
 10022.6 (1.3–10)0.018c (0.009–0.06)
 1442d 3.0 (0.6–9.6)0.054c (0.015–10)
 227111 (7.1–52)0.022c (0.011–0.5)
 28233.2 (0.7–51)0.14c (0.09–0.8)
Patient 40
 16229.9 (0.02–291)0.01c (0.01–3.1)
 22256.6 (0.8–609)0.1c (0.03–0.7)
 251210.4 (02.7–43)0.07c (0.01–0.35)
  • a Total kidney burdens of mice on day 8 after intravenous infection of immune competent mice with 106 CFU of C. albicans isolate per mouse.

  • b Mice were treated with 5 mg of fluconazole (FLU) per kg.

  • c Significantly different from the control value (P < 0.05).

  • d An error was made for mice infected with isolate 1442; the infecting dose was 107 CFU/mouse.