Table 2.

Effect of exogenously added guanosine on the potentiating effect of MPA on the anti-HSV-1 activity of H2G

CultureEC50(μg/ml)a of H2G
AloneIn combination with MPA at indicated concn
10 μg/ml2.5 μg/ml1.0 μg/ml0.25 μg/ml
Without guanosine8.3 ± 0.140.06 ± 0.050.26 ± 0.330.28 ± 0.30.45 ± 0.5
With guanosine (25 μg/ml)4.9 ± 2.65.3 ± 2.66.3 ± 3.66.5 ± 4.8
  • a The EC50 for inhibition of HSV-1-induced CPE by guanosine was >100 μg/ml and >25 μg/ml for MPA. Data are mean values ± standard deviations for three separate experiments.