Table 2.

Survival of neutropenic mice infected with isolates from different patientsa

Patient and isolateMean survival (no. of days) ± SEM of mice given the following FLUb doses (mg/kg):
0 (control)510.50.250.1
Patient 7
 4125 ± 0.317 ± 3c
5 ± 0.524 ± 1.7c
 19078 ± 318 ± 3c
 23078 ± 0.728 ± 2.3c 7 ± 0.4
10 ± 29 ± 1
Patient 14
 5807 ± 223 ± 4c
9 ± 313 ± 2c
 6499 ± 124 ± 3c
 243820 ± 423 ± 4
16 ± 417 ± 3
Patient 43
 164915 ± 328 ± 4c
7 ± 130 ± 1c
 183111 ± 226 ± 3c
 218313 ± 329 ± 1c
6 ± 16 ± 1
Patient 9
 4373 ± 0.314 ± 3c
2 ± 0.26 ± 1c
 10026 ± 310 ± 3c
 14423 ± 0.313 ± 3c
5 ± 0.212 ± 2c 13 ± 3.9c 4 ± 0.4
 22713 ± 0.218 ± 5c
 28234 ± 0.410 ± 2c
7 ± 0.711 ± 0.7c
4 ± 0.35 ± 0.65 ± 0.54 ± 0.2
Patient 40
 16225 ± 0.419 ± 4c
5 ± 0.421 ± 2c
5 ± 0.513 ± 2.9c 8 ± 1.2c 6 ± 0.4
 22254 ± 0.58 ± 2c
 25125 ± 0.617 ± 2c
17 ± 212 ± 3c
5 ± 0.34 ± 0.45 ± 0.24 ± 0.5
  • a Each mouse was infected with 106 CFU of C. albicans isolate.

  • b FLU, fluconazole.

  • c Significantly different from the control value (P < 0.05).