Table 3.

Antiherpesvirus activity of the combination H2G plus ribavirin

Virus (strain)EC50(μg/ml)a of H2G
AloneIn combination with ribavirin at indicated concn
100 μg/ml50 μg/ml25 μg/ml10 μg/ml
HSV-1 (KOS)3.3 ± 3.50.3 ± 0.30.55 ± 0.601.5 ± 1.61.9 ± 2.1
HSV-2 (G)13 ± 8.41.2 ± 0.81.3 ± 0.62.6 ± 1.05.4 ± 2.5
TK HSV-1 (B2006)>1000.54 ± 0.390.75 ± 0.17.1 ± 8.513 ± 13
  • a Concentration required to reduce virus-induced CPE in Vero cells by 50%. The EC50 for ribavirin alone was >100 μg/ml. Data are mean values ± standard deviations for three to five separate experiments.