Table 2.

Percentage of ergosterol among total sterols, cellular concentration of fluconazole, and IC50 for inhibition of sterol 14α-demethylase among the two clinical series ofC. albicans strains

C. albicansisolateErgosterol level (% of total sterol)[14C]fluconazole uptake (pmol/109cells)IC50 (nM)
F189.625.7 ± 2.854.2 ± 4.3
F292.423.1 ± 3.951.7 ± 4.5
F397.212.4 ± 2.359.4 ± 5.3
F496.32.2 ± 0.869.8 ± 4.7
F592.53.2 ± 1.2126.6 ± 5.7
G198.826.4 ± 5.953.8 ± 3.2
G295.925.4 ± 4.756.6 ± 7.5
G396.111.2 ± 3.159.2 ± 4.3
G493.74.2 ± 1.252.6 ± 6.5
G591.21.2 ± 0.9625.9 ± 44.8