Table 1.

In vitro susceptibilities of 1,300 Candidabloodstream isolates to BMS-207147, Sch 56592, and voriconazole versus fluconazole and itraconazole

Organism (no. of isolates) and antifungal agentMIC (μg/ml)
Range50% of isolates90% of isolates
C. albicans(660)
 BMS-2071470.008–>8.00.0080.03
 Sch 565920.008–>8.00.030.06
 Voriconazole0.008–>8.00.0150.06
 Fluconazole0.12–>1280.251.0
 Itraconazole0.015–>8.00.060.25
C. parapsilosis(221)
 BMS-2071470.008–4.00.030.12
 Sch 565920.008–>8.00.120.12
 Voriconazole0.008–2.00.030.12
 Fluconazole0.12–641.02.0
 Itraconazole0.015–2.00.120.5
C. glabrata (217)
 BMS-2071470.008–>8.00.54.0
 Sch 565920.015–>8.01.04.0
 Voriconazole0.03–8.00.52.0
 Fluconazole0.25–>1281664
 Itraconazole0.06–>8.01.04.0
C. tropicalis(139)
 BMS-2071470.008–>8.00.030.25
 Sch 565920.015–>8.00.060.25
 Voriconazole0.008–>8.00.060.25
 Fluconazole0.25–>1280.52.0
 Itraconazole0.03–>8.00.120.5
C. krusei (33)
 BMS-2071470.06–2.00.250.5
 Sch 565920.12–1.00.50.5
 Voriconazole0.06–4.00.51.0
 Fluconazole8.0–1286464
 Itraconazole0.12–2.01.02.0
Candida spp. (30)a
 BMS-2071470.008–8.00.120.5
 Sch 565920.03–>8.00.120.5
 Voriconazole0.008–8.00.060.5
 Fluconazole0.25–1282.08.0
 Itraconazole0.03–>8.00.251.0
All organisms (1,300)
 BMS-2071470.008–>8.00.030.5
 Sch 565920.008–>8.00.061.0
 Voriconazole0.008–>8.00.030.5
 Fluconazole0.12–>1280.516
 Itraconazole0.015–>8.00.121.0
  • a Includes seven C. lusitaniae, seven C. guilliermondii, three C. famata, two C. rugosa, one C. lipolytica, one C. lambica, and nine Candida sp. isolates.