Table 2.

Kis of analogs and Kms of dGTP and dCTP substratesa

SubstrateKm (nM)AnalogKi(nM)Ki/Km
dGTP12.0BMS-200475–TP3.20.27
dGTP13.1Lobucavir-TP4.860.37
dCTP13.03TC-TP41.53.19
  • a Values were calculated from four (BMS-200475-TP) and three (lobucavir-TP, 3TC-TP) independent experiments, respectively, in which baculovirus-derived HBV nucleocapsids were used as a polymerase source (35).