TABLE 6

Antifungal effects of PC945 and posaconazole on other fungal species

Species (strain[s])No. of strains testedCulture methodMIC (μg/ml)a
PC945VoriconazolePosaconazole
Aspergillus carbonarius (ATCC 8740)1CLSI40.50.063
Aspergillus flavus (ATCC 204304)1CLSI>820.13
Aspergillus flavus (AFL8, NRRC3357)2EUCAST60.630.16
Aspergillus niger (ATCC 1015)1EUCAST>810.20
Aspergillus terreus (AT49, AT7130)2EUCAST0.07810.093
Penicillium chrysogenum (ATCC 9480)1CLSI>820.13
Penicillium citrinum (ATCC 9849)1CLSI>8>80.5
Trichophyton rubrum (ATCC 10218)1CLSI0.0310.0630.031
Aureobasidium pullulans (ATCC 9348)1CLSI>8>81
Cladosporium argillaceum (ATCC 38013)1CLSI>80.50.25
Candida albicansb (20240.047, ATCC 10231)2CLSI0.0810.140.081
AR Candida albicansb,c (20183.073, 20186.025)2CLSI8.25108.13
Candida glabratab (ATCC 36583, R363)2CLSI0.58.130.5
Candida krusei (ATCC 6258)1CLSI0.1250.250.125
Chaetomium globosum (ATCC 44699)1CLSI>810.25
Gibberella zeae (Fusarium graminearum) (ATCC 16106)1CLSI>8>8>8
Cryptococcus gattii (clinical isolate)1EUCAST0.250.1250.5
Cryptococcus neoformans (ATCC 24067)1CLSI0.0080.0160.016
Lichtheimia corymbifera (ATCC 7909)1CLSI>8>8>8
Mucor circinelloides (ATCC 8542)1CLSI>8>8>8
Rhizomucor pusillus (ATCC 16458)1CLSI>8>8>8
Rhizopus oryzae (ATCC 11145)1CLSI2>8>8
  • a Due to the limited number of strains tested, the mean isolate MICs are presented.

  • b The MIC given is the MIC50.

  • c AR, azole resistant (fluconazole and voriconazole).