Table 3.

CFU counts in organ homogenates after treatment with moxifloxacin or moxifloxacin plus INH following inoculation of M. tuberculosis

Treatment (daily dose)CFU counta in homogenates of:No. of mice surviving/total no. of mice
LungSpleen
3 weeks
 Control, water7.01 ± 0.596.13 ± 0.4514/16
 Moxifloxacin (20 mg/kg)6.43 ± 0.15b 4.71 ± 0.30c 16/16
 Moxifloxacin (20 mg/kg) + INH (25 mg/kg)2.90 ± 0.36c 3.26 ± 0.32c 16/16
7 weeks
 Control, water4.92 ± 1.424.19 ± 0.764/7
 Moxifloxacin (20 mg/kg)6.40 ± 0.234.27 ± 0.288/8
 Moxifloxacin (20 mg/kg) + INH (25 mg/kg)1.67 ± 1.24c,d 1.84 ± 0.87c,d 8/8
  • a Mice were intravenously inoculated with 1.0 × 107 CFU of M. tuberculosis before treatment. The values given are log10 CFU counts.

  • b Significantly lower than the counts in the control group (P < 0.01).

  • c Significantly lower than the counts in the control group (P < 0.001).

  • d Significantly lower than the counts in the moxifloxacin group (P < 0.001).