Table 1.

Spleen weights of mice after treatment with moxifloxacin, INH, or moxifloxacin plus INH following inoculation of M. tuberculosis

Treatment (daily dose)Mean spleen weight (mg) of mice after treatment for:a
4 weeks8 weeks
Control, water214 ± 26183 ± 55
INH (25 mg/kg)68 ± 14b 93 ± 10b
Moxifloxacin (100 mg/kg)84 ± 24b 71 ± 10b,c
Moxifloxacin (100 mg/kg) + INH (25 mg/kg)71 ± 14b 70 ± 9b,c
  • a Mice (n = 8 for each treatment at each time) were intravenously inoculated with 5.9 × 105 CFU of M. tuberculosis before treatment. Values shown are the means ± standard deviations.

  • b Significantly lower than the weight in the control group (P < 0.001).

  • c Significantly lower than the weight in the INH group (P < 0.01).