Table 2.

Pharmacokinetic parameters in adult humansa and rats used to determine infusion rates for simulation studies with rats

Species, pharmaco-kinetic modelParameterAmoxicillinClavulanate
Human, C(t) = A (exp−kelt− exp−kat)A(μg/ml)284.5
kel(h−1)0.650.61
ka(h−1)1.651.56
Rat, C = a · exp−λt ba(μg/ml)24027
λ (h−1)2.12.4
Dose (mg/kg)4424
  • a Data for humans have been published previously (12).

  • b C is concentration, ais the zero-time intercept, and λ is the elimination rate constant.