Table 4.

Synthetic and semisynthetic antifungal peptides

PeptideStructureMode of actionTypical target organismIn vitro MIC (μg/ml)
Cilofungin (LY121019)LipopeptideGlucan synthesis C. albicans 0.62
D4E1Linear peptideLysis (?) A. flavus 26.25
L731,373LipopeptideGlucan synthesis C. albicans ≤0.06
L733,560LipopeptideGlucan synthesis C. albicans 0.06
L743,872 (MK-0991)LipopeptideGlucan synthesis A. flavus 0.09–3.12
L773,560LipopeptideGlucan synthesis C. albicans 0.5
LY303366LipopeptideGlucan synthesis Candida krusei 0.5