Table 3.

Bacterial and fungal antifungal peptides

PeptideSourceStructureMode of actionTypical target organismIn vitro MIC (μg/ml)
1901-II P. lilacinus Amino-lipopeptideUnknown C. tropicalis 12.5
1907-VIII P. lilacinus Amino-peptideUnknown C. tropicalis 50.0
A12-C B. licheniformis PeptideHyphal proliferation M. canis Unknown
Aculeacins Aspergillus aculeatus LipopeptideGlucan synthesis C. albicans  0.2–6.3a
Aureobasidin A A. pullulans Cyclic depsipeptideActin assembly C. neoformans 0.63
Bacillomycin F Bacillus subtilis LipopeptideLysis Aspergillus niger 40.0
CB-1 B. licheniformis LipopeptideChitin binding F. oxysporum 50.0 (IC50 b)
Cepacidine A1 B. cepacia Cyclic glycopeptideUnknown A. niger 0.098
Cepacidine A2 B. cepacia Cyclic glycopeptideUnknown A. niger 0.096
Echinocandin B A. nidulans LipopeptideGlucan synthesis C. albicans 0.625
Fungicin M-4 B. licheniformis Cyclic peptideUnknown Mucor sp. 8.0
FR900403 Kerniasp.LipopeptideChitin synthesis C. albicans 0.4
Helioferin A M. rosea LipopeptideUnknown C. albicans 5.0
Helioferin B M. rosea LipopeptideUnknown C. albicans 5.0
Iturin A B. subtilis LipopeptideLysis S. cerevisiae 22.0
Leucinostatin A P. lilacinum Amino-lipopeptideUnknown C. neoformans 0.5
Leucinostatin H P. marquandii Amino-lipopeptideUnknown C. albicans 10.0
Leucinostatin K P. marquandii Amino-lipopeptideUnknown C. albicans 25.0
Mulundocandin A. syndowi LipopeptideGlycan synthesis C. albicans, A. niger 0.97
31.25
Nikkomycin X Streptomyces tendae Peptide-nucleosideChitin synthesis C. immitis 0.125
Nikkomycin Z S. tendae Peptide-nucleosideChitin synthesis C. immitis 0.77
Pneumocandin A0 Z. arboricola LipopeptideGlucan synthesis C. albicansisolates0.12–2.0a
Polyoxin D S. cacaoi Trinucleoside peptideChitin synthesis C. immitis 0.125
Pseudomycin A P. syringae LipodepsinonapeptideLysis C. neoformans 1.56
Schizotrin A Schizotrix sp.Cyclic undecapeptideUnknown C. albicans 0.02
Syringomycin E P. syringae LipodepsipeptideLysis C. neoformans  0.8–12.5a
Syringostatin A P. syringae LipodepsipeptideLysis (?) A. fumigatus  5.0–40.0a
Syringotoxin B P. syringae LipodepsinonapeptideLysis (?) C. albicans  3.2–50.0a
Trichopolyn A T. polysporum Amino-lipopeptideUnknown C. neoformans 0.78
Trichopolyn B T. polysporum Amino-lipopeptideUnknown C. neoformans 0.78
WF11899 A Coleophoma empetri LipopeptideGlucan synthesis C. albicans 0.16
WF11899 B C. empetri LipopeptideGlucan synthesis C. albicans 0.008 (IC50)
WF11899 C C. empetri LipopeptideGlucan synthesis C. albicans 0.008 (IC50)
  • a MICs based on assays with multiple isolates.

  • b IC50, inhibitory concentration for 50% of the population.