Table 2.

CFU counts in organ homogenates after treatment with moxifloxacin, INH, or moxifloxacin plus INH following inoculation of M. tuberculosis

Treatment (daily dose)CFU counta in homogenates of:
LungSpleen
4 weeks
 Control, water5.64 ± 0.124.88 ± 0.18
 INH (25 mg/kg)0.38 ± 0.19b 1.23 ± 0.18b
 Moxifloxacin (100 mg/kg)0.63 ± 0.22b 1.51 ± 0.24b
 Moxifloxacin (100 mg/kg) + INH (25 mg/kg)0.17 ± 0.11b 0.66 ± 0.20b,c
8 weeks
 Control, water6.45 ± 0.484.57 ± 0.31
 INH (25 mg/kg)0.10 ± 0.26b 0.49 ± 0.47b
 Moxifloxacin (100 mg/kg)0 ± 0b,d 0.74 ± 0.79b
 Moxifloxacin (100 mg/kg) + INH (25 mg/kg)0 ± 0b,d 0 ± 0b,d
  • a Mice (n = 8 for each treatment at each time) were intravenously inoculated with 5.9 × 105 CFU of M. tuberculosis before treatment. The values given are log10 CFU counts (means ± standard deviations).

  • b Significantly lower than the counts in the control group (P < 0.001).

  • c Significantly lower than the counts in the other treatment groups (P < 0.02).

  • d Zero denotes absence of colonies in any organ homogenates (the lower limit of detection is <0.1).