Table 5.

Susceptibility of SFO-1 to β-lactamase inhibitors

EnzymeBush typeIC50(μg/ml)a
Clavulanic acidImipenem
SFO-12e0.10.35
FEC-12e0.00220.13
Chromosomal β-lactamase of P. vulgaris 2e0.60.62
TEM-12b1.014
Chromosomal β-lactamase of E. cloacae 1120.24
Chromosomal β-lactamase ofE. coli 17.81.4
  • a IC50, concentration that inhibits 50% of activity after 10 min of incubation at 37°C; nitrocefin was used as the substrate.