Table 4.

Duration of time and percentage of dosing interval above the MIC of amoxicillin-clavulanate at the doses resulting in levels in rat serum simulating those achieved in humans

MIC (μg/ml)T >MIC (h) (% of 24-h dosing period)
Amoxicillin-clavulanate (500/125 mg t.i.d.)Amoxicillin-clavulanate (875/125 mg b.i.d.)
80 (0)3.8 (16)
46.2 (26)7.2 (30)
210.3 (43)9.6 (40)
115.4 (64)12.5 (52)