Table 1.

Frequencies of appearance of mutant strains by selection with various quinolones

Selecting quinoloneFrequency at the following multiple of the MICa:
16×32×
Gatifloxacin<1.1 × 10−9 <1.1 × 10−9 <1.1 × 10−9 <1.1 × 10−9 <1.1 × 10−9
Sparfloxacin>2.2 × 10−6 >2.2 × 10−6 >2.2 × 10−6 1.1 × 10−7 <1.1 × 10−9
Trovafloxacin>2.2 × 10−6 6.2 × 10−8 <1.1 × 10−9 <1.1 × 10−9 <1.1 × 10−9
Levofloxacin1.5 × 10−7 <1.1 × 10−9 <1.1 × 10−9 <1.1 × 10−9 <1.1 × 10−9
Ciprofloxacin>2.2 × 10−6 1.1 × 10−9 <1.1 × 10−9 <1.1 × 10−9 <1.1 × 10−9
Norfloxacin2.6 × 10−7 2.2 × 10−9 <1.1 × 10−9 <1.1 × 10−9 <1.1 × 10−9
  • a The reproducibilities of the frequencies have been confirmed in repeated experiments.