Table 1.

Influence of urinary pH on ciprofloxacin pharmacokinetics in plasma: a comparison between pharmacokinetic variables on three separate occasions under different conditions of urinary pH

Pharmacokinetic variablesaResultb(SD) under treatment with:
NaHCO3NH4ClH2O
C max(μg/ml)1.729 (0.33)1.506 (0.238)1.804 (0.421)
T max(h)1.2 (0.2)1.3 (0.5)1.0 (0.4)
t 1/2(h)4.6 (1.6)4.3 (1.1)4.2 (0.8)
AUC (μg · h/ml)5.147 (0.680)5.320 (0.770)5.649 (0.884)
CL/F(liters/h)37.971 (6.711)39.011 (5.599)37.464 (5.194)
V/F(liters)248.762 (78.602) 234.484 (46.28)223.377 (37.52)
CLR(liters/h)16.08 (3.02)16.78 (2.67)16.31 (2.67)
Ae (mg)82.4 (16.5)88.4 (14.5)90.53 (9.8)
  • a Tmax, time to peak concentration in plasma; t 1/2, apparent elimination half-life; AUC, area under the plasma concentration-time curve (0 to 24 h); CL/F, apparent total body clearance;V/F, apparent volume of distribution; CLR, renal clearance; Ae, amount of unchanged drug excreted.

  • b The pharmacokinetic parameters were calculated according to a two-compartment open model with first-order absorption. ANOVA was utilized to describe significant differences in the pharmacokinetic parameters and urinary pH; all differences were not significant.