Table 3.

Aminoglycoside pharmacokinetic and pharmacodynamic variables for 78 patients with pneumonia caused by gram-negative bacteria

VariableMedian (interquartile range)
Aminoglycoside CL (ml/min/1.73 m2)71.5 (50.4–91.3)
Aminoglycoside half-life (h)3.5 (2.6–5.0)
AUC0–24 (μg · h/ml)52.2 (34.5–77.5)
AUC0–48 (μg · h/ml)104.9 (81.9–142.9)
AUC0–72 (μg · h/ml)168.8 (130.7–219.0)
AUC24 (μg · h/ml)56.5 (42.9–75.3)
FirstCmax/MIC3.6 (1.4–6.2)
FirstCmin/MIC0.3 (0.2–0.7)
SecondCmax/MIC3.7 (1.9–6.9)
SecondCmin/MIC0.4 (0.2–0.8)
AUC0–24/MIC (SIT−1 · 24 h)38.7 (13.9–67.2)
AUC0–48/MIC (SIT−1 · 24 h)77.0 (25.8–131.2)
AUC0–72/MIC (SIT−1 · 24 h)113.6 (40.8–199.9)
AUC24/MIC (SIT−1 · 24 h)38.9 (14.6–60.0)