Table 1.

The effect of antimalarial drugs and inhibitors on the rate of P. falciparum oxygen consumption

First inhibitorbSecond inhibitorRate of O2 consumption (% inhibition)a
UninhibitedFirst inhibitorBoth inhibitors
AtovaquoneProguanil4.2 ± 0.8c 1.6 ± 0.2c (61%)1.4 ± 0.2c (64%)
ProguanilAtovaquone4.7 ± 0.5d 4.4 ± 0.4d (6%)1.2 ± 0.7d (74%)
ProguanilSHAM4.1 ± 0.7d 3.6 ± 0.9d (10%)2.0 ± 0.6d (52%)
  • a The rate of O2 consumption is in nanomoles per minute. The percent inhibition of the total rate of parasite oxygen is indicated in parentheses.

  • b The concentrations of the inhibitors used were 50 nM atovaquone, 1 mM proguanil, and 1 mM SHAM.

  • c Results are the means of three experiments ± the standard deviation.

  • d Results are the means of duplicate experiments ± the range.