Table 2.

Amount of unchanged drug excreted into urine at various time periods after treatment with ammonium chloride, sodium bicarbonate, or watera

Collection period (h)Amt (mg) of unchanged drug (SD) under treatment with:
NaHCO3NH4ClH2O
0–222.426 (9.679)24.756 (8.564)26.251 (5.156)
2–420.099 (6.690)19.877 (5.327)21.988 (9.145)
4–612.763 (3.253)12.695 (5.696)13.700 (3.366)
6–88.220 (2.015)11.098 (5.958)9.314 (3.884)
8–1210.935 (2.269)10.116 (2.546)10.598 (2.410)
12–249.899 (2.604)8.304 (3.246)8.608 (3.927)
  • a ANOVA was utilized to describe significant differences; all differences were not significant.