Table 2.

Results for M. bovis BCG treated with fluoroquinolones while inside human macrophages

StrainFluoroquinoloneConcn (μg/ml)No. of CFU ata:Survival (% of that on day 0)
Day 0Day 2 postinfection
KD1295 (WT)None03.7 × 104 2.2 × 104 59.4
PD161148 (C8-OMe)24.0 × 101 0.11
600
1000
PD160793 (C8-H)27.6 × 102 2.0
63.3 × 102 0.89
1000
Ciprofloxacin26.0 × 103 16
61.5 × 102 0.41
1000
CX1 (Cipr)None06.3 × 104 2.0 × 104 32
PD161148 (C8-OMe)22.6 × 103 4
62.5 × 103 4
102.8 × 103 4
PD160793 (C8-H)28.1 × 104 130
64.2 × 104 67
101.5 × 104 24
Ciprofloxacin23.5 × 104 55
63.7 × 104 59
101.0 × 104 16
  • a Values are means for two wells. Similar results were obtained in two replicate experiments.