Table 2.

Aminoglycoside dosing characteristics for 78 patients with pneumonia caused by gram-negative bacteria

VariableBefore IPM (n = 78)After IPM (n = 60)
Aminoglycoside dose (mg)a105 (90–140)230 (175–320)
Dosing interval (no. [%] of patients)
 6 h1 (1)0 (0)
 8 h16 (21)15 (19)
 12 h49 (63)37 (48)
 18 h4 (5)8 (10)
 24 h8 (10)17 (22)
 36 h0 (0)1 (1)
Cmax(μg/ml)a5.3 (3.9–6.3)6.7 (5.2–7.6)
Cmin(μg/ml)a0.6 (0.3–1.1)0.8 (0.5–1.1)
  • a Values are medians (interquartile ranges).