Table 1.

In vitro activities of TBG-MINO, DMG-MINO, DMG-DMDOT, minocycline, and tetracycline against strains with characterized tetracycline resistanceā€‰determinants

OrganismStrainResistance determinantMIC (Ī¼g/ml)
TBG-MINODMG-MINODMG-DMDOTMinocyclineTetracycline
E. coli UBMS 88-1 tet(B)0.50.50.516>32
E. coli MC4100 tet(B)0.50.50.58>32
E. coli J3272, pRP1 tet(A)0.522432
E. coli J3272, pBR322 tet(C)0.25224>32
E. coli J3272, pRA1 tet(D)0.250.250.258>32
E. coli UBMS 90-4 tet(M)0.250.250.25>32>32
E. coli UBMS 90-5Sensitive0.250.50.2511
E. coli ATCC 25922Control0.250.250.250.51
S. aureus UBMS 88-7 tet(K)0.5110.25>32
S. aureus UBMS 88-5 tet(M)0.50.250.254>32
S. aureus UBMS 90-1 tet(M)0.250.250.124>32
S. aureus UBMS 90-2 tet(M)0.250.250.25232
S. aureus UBMS 90-3Sensitive0.250.250.120.060.12
S. aureus ATCC 29213Control0.50.250.250.060.25
S. aureus SmithSensitive0.250.250.120.060.12
E. faecalis UBMS 90-6 tet(M)0.250.120.2516>32
E. faecalis ATCC 29212Control0.250.120.1218
N. gonorrhoeae 6418 tet(M)11116>32