Table 4.

In vitro activities of TBG-MINO and comparative antibiotics against anaerobic bacteria

Organism (no. of isolates)AntibioticMIC (μg/ml)
Range50%90%
Bacteroides fragilis group (12)TBG-MINO0.25–20.52
DMG-MINO0.25–0.50.250.5
DMG-DMDOT0.25–0.50.250.5
Minocycline0.06–424
Cefoxitin2–>3216>32
Imipenem≤0.06–20.122
Bacteroides fragilis(14)TBG-MINO0.5–822
DMG-MINO0.25–211
DMG-DMDOT0.5–212
Minocycline≤0.06–888
Cefoxitin1–888
Imipenem≤0.06–0.25≤0.060.12
Prevotella spp. (11)TBG-MINO0.12–10.51
DMG-MINO≤0.06–0.50.250.5
DMG-DMDOT≤0.06–20.52
Minocycline≤0.06–16816
Cefoxitin0.25–412
Imipenem ≤0.06≤0.06≤0.06
Clostridium difficile(10)TBG-MINO≤0.06–0.250.120.12
DMG-MINO≤0.06–0.120.120.12
DMG-DMDOT≤0.06–0.120.120.12
Minocycline≤0.06–40.034
Cefoxitin>32   >32>32
Imipenem2–1644
Clostridium perfringens (10)TBG-MINO0.12–40.51
DMG-MINO0.12–40.252
DMG-DMDOT0.12–40.252
Minocycline≤0.06–8≤0.064
Cefoxitin0.25–10.51
Imipenem ≤0.06≤0.06≤0.06
Anaerobic gram-positive cocci (15)TBG-MINO≤0.06–0.250.120.25
DMG-MINO≤0.06–0.12≤0.060.12
DMG-DMDOT≤0.06–0.50.120.5
Minocycline0.12–16416
Cefoxitin≤0.06–160.1216
Imipenem≤0.06–1≤0.061