Table 1.

Alterations in gyrA and parC genes in clinical isolates of E. faceium

ATCC strainMIC (μg/ml)aAmino acid (codon) at positionb
CIPTRVGyrAParC, 80
8387
1943441Ser (AGT)Glu (GAG)Ser (AGC)
379710.125
21684
214328Lys (AAG)Ile (ATC)
211328Lys (AAG)Ile (ATC)
2093216Lys (AAG)Ile (ATC)
2102568Lys (AAG)Ile (ATC)
3784>2564Lys (AAG)Ile (ATC)
2086416Arg (CGT)Ile (ATC)
22125632Ile (ATT)Ile (ATC)
2152568Tyr (TAT)Ile (ATC)
213>25616Tyr (TAT)Ile (ATC)
212>25632Tyr (TAT)Ile (ATC)
  • a CIP, ciprofloxacin; TRV, trovafloxacin.

  • b Positions correspond to E. coli. For those strains with no amino acid shown, the codon is identical to that of the type strain.