TABLE 2

Predicted median piperaquine trough (Cmin,ss) and peak (Cmin,ss) plasma concentrations at steady state and the first trough concentration (Cmin,1) for each dosing scenario at different adherence levels

Dosing scheduleaScenarioPiperaquine concn (ng/ml) at various adherence levels
(A: 100%)(B: 80%)(C: 60%)(D: 60% + 30% IIV)
Cmax,ssCmin,ssCmin,1Cmax,ssCmin,ssCmin,1Cmax,ssCmin,ssCmin,1Cmax,ssCmin,ssCmin,1
Monthly maintenance1: No loading dose236.327.514.0214.620.812.5186.715.411.1192.714.811.6
2: One loading dose231.527.518.3215.120.815.9188.815.614.3190.415.013.8
3: Two loading doses238.128.422.7208.220.619.8188.414.717.1190.215.916.7
Weekly maintenance (three tablets)4: No loading dose218.547.99.7208.237.39.9185.425.89.7189.925.19.8
5: One loading dose219.848.420.7203.535.920.8190.024.320.8188.525.020.9
6: Two loading doses215.148.833.6201.634.531.2186.126.128.6189.425.328.2
7: Three loading doses221.147.951.5204.536.945.9188.826.239.3203.127.938.4
8: Four loading doses218.348.873.1202.835.963.4190.225.452.1188.625.350.5
Weekly maintenance (two tablets)9: No loading dose141.031.75.9137.824.65.6125.816.85.7124.916.55.7
10: One loading dose145.332.111.8136.824.212.3125.416.611.9124.816.612.0
11: Two loading doses146.832.919.3136.823.918.2125.916.215.7124.616.916.4
12: Three loading doses147.733.028.3128.316.520.9129.717.220.8129.717.120.8
13: Four loading doses144.932.340.1135.124.132.5128.617.026.9127.216.927.4
  • a Details for each specific dosing are specified in Fig. 1. Scenario numbers correspond to those listed in Fig. 1.