Table 2.

Effect of time of lipopolyamine administration on LPS-induced lethality in d-galactosamine-sensitized mice

GroupaTime of lipopolyamine administrationbNo. of dead mice/total no. of mice tested
DOSPER
 1Control11/12
 2−1 h10/12
 3−15 min3/12c
 40 h1/12c
 5+1 h7/11
 6+2 h7/12
 7+4 h7/12
DOGS
 1Control10/10
 2−1 h6/10
 30 h0/10c
 4+1 h5/10
 5+2 h9/10
 6+4 h9/10
  • a Eachd-galactosamine-sensitized mouse received 20 mg of S. abortus equi LPS.

  • b DOGS or DOSPER dose, 40 μg/mouse. Control animals received 0.2 ml of saline instead of lipopolyamine. 0 h, lipopolyamine was injected into the animals i.p. immediately after LPS and d-galactosamine challenge.

  • c P < 0.005.