Table 3.

Protective effect of DOSPER ind-galactosamine-sensitized mice challenged with E. coli and cell wall-active antibiotics

E. coli challenge (CFU/mouse)No. of dead mice/total no. of mice treated with the followinga:
SalineSaline + DOSPERImipenem + salineImipenem + DOSPERCeftazidime + salineCeftazidime + DOSPER
102 0/6
103 4/63/50/40/4
104 6/64/10b 0/101/10
105 9/106/102/98/102/10b
106 10/106/107/1010/106/10b
107 5/59/107/10
  • a DOSPER (40 μg/mouse) and imipenem (0.5 mg/mouse) or ceftazidime (1.0 mg/mouse) were administered at the same time as the E. coli challenge. Results shown are collated from two separate experiments.

  • b P < 0.005.