Table 5.

In vivo activities of TBG-MINO, DMG-DMDOT, and minocycline against experimental acute lethal S. aureus Smith infection in micea

AntibioticRouteED50 (mg/kg) (95% confidence limit)MIC (μg/ml)
TBG-MINOIntravenous0.64 (0.51–0.80)0.25
TBG-MINOOral36 (28–45)0.25
DMG-DMDOTIntravenous0.51 (0.41–0.64)0.12
DMG-DMDOTOral21 (16–26)0.12
MinocyclineIntravenous0.53 (0.40–0.70)0.06
MinocyclineOral0.52 (0.40–0.69)0.06
  • a Challenge dose, 6.2 × 105 CFU/mouse.