Table 2.

In vitro activities of TBG-MINO and comparative antibiotics against gram-positive isolates

Organism (no. of isolates)AntibioticMIC (μg/ml)
Range50%90%
Staphylococcus aureus, methicillin resistant (12)TBG-MINO0.25–10.50.5
DMG-MINO0.12–20.252
DMG-DMDOT0.25–20.52
Minocycline0.03–40.121
Tetracycline0.25–>320.5>32
Ciprofloxacin0.25–>32832
Vancomycin0.5–211
Erythromycin4–>32>32>32
Staphylococcus aureus, methicillin susceptible (13)TBG-MINO   0.5 0.50.5
DMG-MINO0.25–0.50.50.5
DMG-DMDOT   0.5 0.50.5
Minocycline   0.120.120.12
Tetracycline   0.5 0.50.5
Ciprofloxacin0.5–10.51
Vancomycin0.5–111
Erythromycin0.5–10.50.5
Coagulase-negative staphylococci, methicillin resistant (13)TBG-MINO0.25–20.51
DMG-MINO0.25–80.54
DMG-DMDOT0.12–818
Minocycline0.12–10.51
Tetracycline0.25–>324>32
Ciprofloxacin0.25–>320.532
Vancomycin1–222
Erythromycin0.12–>32>32>32
Coagulase-negative staphylococci, methicillin susceptible (16)TBG-MINO0.12–0.50.250.5
DMG-MINO0.12–0.50.250.5
DMG-DMDOT0.12–10.250.5
Minocycline0.06–0.50.120.25
Tetracycline0.12–320.532
Ciprofloxacin0.12–10.250.5
Vancomycin1–212
Erythromycin0.12–>320.121
Enterococcus faecalis(11)TBG-MINO0.12–0.50.250.5
DMG-MINO0.06–0.250.250.25
DMG-DMDOT0.12–0.50.250.25
Minocycline0.06–1688
Tetracycline0.25–323232
Ciprofloxacin1–3212
Vancomycin1–422
Erythromycin1–1618
Enterococcus faecium(11)TBG-MINO0.12–0.250.250.25
DMG-MINO0.06–0.120.120.12
DMG-DMDOT0.12–0.250.120.12
Minocycline0.06–160.064
Tetracycline0.25–>320.2532
Ciprofloxacin1–444
Vancomycin0.25–212
Erythromycin0.5–>324>32
Enterococcus spp., vancomycin resistant (10)TBG-MINO0.12–0.250.250.25
DMG-MINO0.06–0.250.120.25
DMG-DMDOT0.12–0.250.120.25
Minocycline0.06–80.068
Tetracycline0.25–>320.25>32
Ciprofloxacin0.5–444
Vancomycin>32   >32>32
Erythromycin>32   >32>32
Streptococcus pneumoniae, penicillin resistant (10)TBG-MINO0.06–0.250.120.12
DMG-MINO0.03–0.120.060.06
DMG-DMDOT0.06–0.120.120.12
Minocycline0.12–844
Tetracycline0.5–323232
Vancomycin0.25–0.50.50.5
Streptococcus pneumoniae, penicillin susceptible (10)TBG-MINO0.06–0.120.060.12
DMG-MINO0.06–0.250.060.12
DMG-DMDOT0.06–0.50.060.12
Minocycline0.06–0.50.120.12
Tetracycline0.12–40.250.5
Vancomycin0.12–10.50.5
Streptococcus pyogenes (10)TBG-MINO0.12–0.50.120.25
DMG-MINO0.06–0.120.120.12
DMG-DMDOT0.120.120.12
Minocycline0.06–0.250.060.12
Tetracycline0.25–160.250.25
Vancomycin0.5 0.50.5
Streptococcus agalactiae(10)TBG-MINO0.12–0.50.120.25
DMG-MINO0.12–0.50.120.5
DMG-DMDOT0.12–10.120.25
Minocycline0.12–161616
Tetracycline0.25–323232
Vancomycin0.5–10.50.5