TABLE 2

Drug concentrations at 2 h postdosing in different groups of patientsa

CharacteristicNo. (%) of patientsMedian (IQR) concn (μg/ml)
RMPINHPZA
Sex
    Male1,291 (68)2.3 (0.7–4.8)7.4 (4.5–11.0)32.3 (23.7–40.5)
    Female621 (32)2.3 (0.6–5.4)7.7 (4.4–11.4)35.1 (24.9–45.4)
        P value0.4700.235<0.001
Age (yr)
    18–591,754 (92)2.3 (0.6–4.9)7.4 (4.4–10.9)33.3 (23.9–41.4)
    >60158 (8)2.8 (1.0–6.0)9.0 (5.5–12.0)36.9 (24.5–44.9)
        P value0.033<0.0010.038
Smoker
    Yes612 (32)2.3 (0.7–4.8)7.8 (5.0–11.0)33.3 (25.3–40.8)
    No1,300 (68)2.3 (0.6–5.0)7.4 (4.3–11.0)33.5 (23.5–42.0)
        P value0.8440.0720.733
Alcohol user
    Yes742 (39)2.3 (0.7–4.7)7.7 (4.9–11.1)33.5 (25.0–41.5)
    No1,170 (61)2.3 (0.6–5.1)7.4 (4.2–11.0)33.5 (23.5–42.0)
        P value0.5900.2320.953
Smear statusb
    Positive887 (71)2.3 (0.6–4.9)7.9 (4.7–11.3)34.5 (24.1–42.3)
    Negative354 (29)2.4 (0.8–5.3)7.7 (4.9–11.4)33.4 (24.9–43.0)
        P value0.3400.9380.913
Diabetes
    Yes452 (24)2.3 (0.7–4.9)6.6 (3.9–9.8)31.0 (22.3–38.0)
    No1,460 (76)2.3 (0.6–5.0)7.8 (4.7–11.3)34.1 (24.6–42.7)
        P value0.858<0.001<0.001
Baseline INH susceptibilityc
    Sensitive598 (92)2.2 (0.6–4.8)8.0 (4.6–11.3)34.5 (24.1–42.8)
    Resistant53 (8)2.6 (0.5–5.8)9.0 (5.7–11.4)37.9 (29.1–44.0)
        P value0.3760.4420.127
Body wt (kg)
    ≤48961 (50)2.3 (0.7–5.2)8.4 (5.0–12.0)37.6 (25.3–46.0)
    >48951 (50)2.3 (0.6–4.8)6.8 (4.0–9.7)30.6 (23.0–37.1)
        P value0.1681<0.001<0.001
Disease
    PTB1,241 (65)2.3 (0.6–5.0)7.9 (4.7–11.3)34.1 (24.4–42.6)
    EPTB671 (35)2.3 (0.6–5.0)7.0 (4.0–10.2)32.2 (23.5–39.8)
        P value0.9810.0010.003
Category of ATT
    I1,659 (87)2.3 (0.7–5.0)7.4 (4.6–11.0)33.4 (24.3–41.6)
    II253 (13)2.2 (0.6–4.9)7.8 (4.0–11.4)33.7 (20.5–42.3)
        P value0.9600.7800.487
  • a Data are for 1,912 patients unless indicated otherwise.

  • b Data are only for pulmonary TB patients (n = 1,241).

  • c Data are only for culture-positive cases (n = 651).