Table 1.

Activities of PNU-100480, linezolid, and eperezolid compared to that of INH in murine model of tuberculosis

Treatment groupaLog10CFU/organ (mean ± SD)
SpleenLung
Late Controlsb 7.63 ± 0.20 (5)c 8.47 ± 0.51 (5)
INHd 4.36 ± 0.31 (6)3.81 ± 0.17 (6)
PNU-100480e 4.61 ± 0.26 (6)3.59 ± 0.33 (4)
Linezolid5.24 ± 0.32 (8)5.03 ± 0.45 (8)
Eperezolidf 7.07 ± 0.49 (7)7.77 ± 0.11 (4)
  • a Treatment was started 1 day after the mice received 7 × 106 viable mycobacteria.

  • b Three mice died (days 12, 18, and 22).

  • c Values in parentheses are numbers of mice per group.

  • d Two mice died (days 3 and 9).

  • e Two mice died (days 9 and 31); data for lungs are based on data for only four mice due to contamination.

  • f Eight mice were killed; however, for one spleen and four lungs the mycobacteria on the titer plates were too numerous to count.