Table 1.

MICs of amphotericin B, rifampin, and flucytosine alone and in combinationa

StrainMIC (μg/ml)FIC index
AMBRIF5FCAMB +  RIFAMB +  5FCAMB +  RIFAMB +  5FC
FMR 52072.31>40>322.751.16/0.621.16/5.040.510.51
FMR 43911.16>40>322.751.16/0.621.16/5.041.011.01
FMR 49281.16>40>322.751.16/0.621.16/5.041.011.01
FMR 49271.16>40>322.751.16/0.621.16/5.041.011.01
FMR 49311.16>40>322.751.16/0.621.16/5.041.011.01
  • a Tests were performed with fungal inocula of 103 conidia/ml at 30°C and 48 h of incubation. FIC, fractional inhibitory concentration; AMB, amphotericin B; RIF, rifampin; 5FC, flucytosine.