Table 3.

Activities of PNU-100480 in combination with INH or RIF against M. tuberculosis ATCC 35801

Treatment groupaLog10CFU/organ (mean ± SD)
SpleenLung
Early controls (7)b 7.62 ± 0.215.96 ± 0.30
Late controlsc
PNU-100480 (8)3.87 ± 0.382.75 ± 0.44
INH (7)d 3.95 ± 0.383.11 ± 0.30
RIF (7)d 3.79 ± 0.713.35 ± 0.43
INH-RIF (7)d 3.19 ± 0.563.05 ± 0.66
PNU-100480–INH (7)d 3.93 ± 0.202.90 ± 0.45
PNU-100480–RIF (7)e 3.24 ± 0.592.55 ± 0.40
  • a Treatment was started 1 week after the mice received 2 × 107 viable mycobacteria.

  • b Values in parentheses are numbers of mice per group.

  • c Five mice were dead 14 days after infection. Technical problems occurred with the other mice; therefore, organ counts are not available.

  • d One mouse in each group died between day 9 and day 11 after infection.

  • e Organ cultures for one mouse were contaminated.