Table 1.

Nikkomycin Z MICs and FICs for clinical fungal isolates

Species (no. of isolates)Nikkomycin Z MIC (μg/ml)FIC of nikko-mycin Z with:
RangeMIC50aFlucon-azoleItracon-azole
C. albicans(15)<0.5–3240.480.2
C. tropicalis (4)>64>64>1>1
C. krusei (4)>64>64>1>1
C. glabrata (3)>64>64>1>1
C. parapsilosis (4)1–420.320.46
Cryptococcus neoformans(15)<0.5–>64>640.720.49
Scedosporium spp. (2)>64>64>1>1
Paecilomyces spp. (2)>64>64>10.83
Trichoderma spp. (2) 6464>10.71
Penicillium spp. (2)>64>64>10.83
Fusarium spp. (2)>64>64>1>1
A. fumigatus (13)>64>64>10.35
A. flavus(13)>64>64>10.33
A. niger(7)>64>64>1>1
A. versicolor(1)>64>64>1>1
A. nidulans(1)>64>64>10.52
Coccidioides immitis(10)1–1640.440.47
E. jeanselmia(3)>64>64>1>1
E. spinifera(1)>64>64>1NAc
Bipolaris spp. (2)>64>640.64NA
W. dermatitidis (1)>64>64>10.56
O. humicola (1) 44>1>1
P. werneckii (1)>64>64>1>1
Cladophialophora bantiana (1)>64>64>1>1
  • a MIC50, MIC at which 50% of the isolates were inhibited.

  • b FICs were based on the MIC80s for all isolates except those of C. albicans, C. parapsilosis, and Cryptococcus neoformans, for which MIC100s were used (Table 2).

  • c NA, not applicable. Itraconazole MICs for these organisms were at the lowest concentration tested; therefore, the drug interaction could not be determined.