Table 1.

Results of MIC testing of multipleCandida speciesa

IsolateSpecies24-/48-h MICMIC phenotype
YADRPMIYADRPMI
707-15C. albicans0.5/40.5/>64L/LL/H
630-11C. albicans2/42/>64L/LL/H
623-11C. albicans2/22/>64L/LL/H
578-8C. albicans2/22/>64L/LL/H
572-10C. albicans4/82/>64L/LL/H
34-504-040C. albicans2/22/64L/LL/H
34-028-117C. albicans2/21/>64L/LL/H
630-20C. albicans2/42/>64L/LL/H
34-023-096C. albicans2/21/>64L/LL/H
34-013-027Candida parapsilosis8/162/8L/LL/L
572-9C. parapsilosis16/864/>64L/LH/H
34-013-0129C. parapsilosis1/464/>64L/LH/H
572-36C. tropicalis0.5/80.25/64L/LL/H
572-35.1C. tropicalis2/24/>64L/LL/H
A9763Saccharomyces cerevisiae16/168/16L/LL/L
707-9Candida lipolytica64/>6464/>64H/HH/H
Y533C. lusitaniae4/41/>64L/LL/H
34-013-028C. lusitaniae0.25/464/>64L/LH/H
559-7.1C. lusitaniae8/164/8L/LL/L
625-4Candida glabrata3/864/>64L/LH/H
625-4C. glabrata64/>6416/64H/HH/H
572-32C. glabrata64/>6416/64H/HH/H
630-10Candida krusei64/>6464/64H/HH/H
A6258C. krusei64/>6464/>64H/HH/H
9013-8C. krusei64/6464/>64H/HH/H
  • a Shown are 24- and 48-h MICs and the MIC phenotype (as defined in Materials and Methods) in unbuffered YAD (pH 4.5) and MOPS-buffered RPMI 1640 (pH 7.0). Note that all isolates having a low-high (L/H) phenotype in RPMI 1640 had a low-low (L/L) phenotype in YAD. Isolate 707-15, used in many of the experiments in this study, was tested in an animal model and was found to respond as a fluconazole-susceptible isolate (10). Isolates having MICs that resulted in discrepant susceptibility interpretations (L/L versus high-high [H/H] phenotypes) are highlighted in boldface.