Table 2.

Outcome of 3-day treatment of experimental GISA aortic valve endocarditis with vancomycin-nafcillin

IsolateTreatment regimenNo. of rabbits surviving/no. treatedOrganism count (mean ± SD log10CFU/g)
Aortic valveKidneya
HIP5827Controls6/1110.3 ± 0.517.46 ± 0.06 (0/11)
Vancomycin9/99.66 ± 1.13.14 ± 1.39b (0/9)
Nafcillin6/78.79 ± 0.82b 3.13 ± 2.04b (2/7)
Vancomycin + nafcillin9/95.77 ± 1.59c 1.54 ± 1.63b (8/9)d
MU50Controls0/810.31 ± 0.378.35 ± 0.97 (0/8)
Vancomycin4/69.43 ± 0.744.20 ± 3.26b (2/6)
Nafcillin2/79.46 ± 1.145.52 ± 3.11b (1/7)
Vancomycin + nafcillin6/76.25 ± 2.27c 3.03 ± 2.80b (4/7)e
  • a Values in parentheses are numbers of rabbits with sterile kidneys/number of rabbits treated.

  • b P < 0.05 versus vancomycin, nafcillin, and control groups.

  • c P < 0.05 for all regimens versus controls.

  • d P = 0.0001 versus vancomycin and control groups; P = 0.035 versus nafcillin group by Fisher’s exact test.

  • e P = 0.026 versus controls by Fisher’s exact test.