Table 1.

Sterilization of various tissues with oxacillin (50 mg/kg, three times daily) alone or with oxacillin combined with either free amikacin or MiKasome in an experimental S. aureusendocarditis model

RegimenNo. of sterile samples/total no. of samples (%)
VegetationMyocardiumKidney
3 days6 daysRelapsea3 days6 daysRelapse3 days6 daysRelapse
Oxacillin0/9 (0)2/10 (20)0/7 (0)1/9 (11)4/10 (40)1/7 (14)2/9 (22)7/10 (70)0/7 (0)
Oxacillin + free amikacin0/8 (0)2/9 (22)2/9 (22)1/8 (13)4/9 (44)3/9 (33)4/8 (50)7/9 (78)7/9 (78)
Oxacillin + MiKasome1/9 (11)5/6 (83)5/10 (50)4/9 (44)6/6 (100)2/10 (20)5/9 (56)6/6 (100)8/10 (80)
  • a Relapse, 5 days posttherapy.