Table 2.

Survival of mice infected intravenously withH. capsulatuma

Study and inoculum (CFU)Drug or treatmentDose (mg/kg)No. of days of survivalNo. alive at day 30
MeanSEM
Study A (2.0 × 106)ControlNone15.22.92
GM22030b010
1028.4b2.69
529.1b1.99
230b010
Amphotericin B130b010
0.530b010
Fluconazole1023.24.07
520.13.75
Study B (108)ControlNone 4.00.140
GM35 6.7b0.90
1.25 4.90.40
0.3 4.00.30
0.06 4.10.20
Amphotericin B1.2528.4b2.69
0.3 4.80.20
Fluconazole1013.1b3.22
  • a Mice were treated from day 2 through 8 after infection, and their rates of survival were observed through day 30. Ten mice were in each treatment group.

  • b P < 0.001 compared with the control group.